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Zyflamend: Ease Pain And Inflammation Of Arthritis And May Possess Cancer-Fighting Properties


Like most people you’ve probably resorted to taking non-steroidal anti-inflammatory drugs (NSAIDs) – over-the-counter painkillers like aspirin and ibuprofen – from time-to-time, to help relieve a persistent headache or nagging toothache that just won’t go away. You may even be taking them on a regular basis to alleviate a more chronic problem such as arthritis.

However, analgesics like these can cause a host of harmful side effects, including gastrointestinal disorders. What many people aren’t aware of is that natural alternatives exist, which can banish pain without causing any adverse effects. Ten herbs that have been found to be particularly beneficial in this area are holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano and scutellaria.

Now, following extensive research into their individual pain-relieving properties, these 10 herbs have been combined into a new formula called Zyflamend. Zyflamend has been found to offer effective relief against pain caused by inflammatory conditions such as arthritis.

Zyflamend helps put the breaks on a pain-causing mechanism in your body

Zyflamend works in a similar way to NSAIDs, killing pain by decreasing the production of pro-inflammatory prostaglandins (hormone-like substances), which are generated by the cyclooxygenase (COX) enzyme.

There are in fact two cyclooxygenase enzymes – cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 has many important functions in your cells and is continually being produced by your body. These functions include regulation of blood flow, platelet function, gastro-intestinal protection and regulation of kidney function. However, while the correct amount of COX-2 in the body is also vital for a number of biological functions, if its activity increases (often caused by an excess consumption of red meat, saturated fats and refined vegetable oils) so too does the presence of pain and inflammation.

Like NSAIDs, Zyflamend works by suppressing the effect of COX-2. Not only does this help control pain but there is also mounting evidence to suggest that this action may even protect against cancer, as raised COX-2 activity appears to increase the incidence of cancer. For example, a number of studies have found elevated levels of COX-2 in prostate cancer cells.1

In addition, COX-2 is 60 times more prevalent in a cancerous pancreas than in a normal one and the enzyme may be present in up to 90 per cent of patients suffering from rectal cancer.2

How the 10 herbs in Zyflamend work to combat pain and inflammation

The individual herbs contained in Zyflamend have each been extensively studied for their pain-relieving properties and potential anti-cancer activity. They include:

  • ** Holy Basil. Indigenous to India, holy basil (not to be confused with common basil that is used as a culinary herb) contains ursolic acid. Research carried out at Dartmouth Medical School suggests that a strong link exists between ursolic acid’s anti-inflammatory and anti-cancer actions and its ability to inhibit COX-2.3
  • ** Turmeric. The active constituent of turmeric, a common ingredient added to curries, is a plant chemical called curcumin. It has been shown to reduce inflammation by lowering histamine levels and preventing the overproduction of COX-2. Researchers conducting a preliminary trial involving rheumatoid arthritis patients found that curcumin was beneficial in reducing inflammation, pain and stiffness.4
  • ** Ginger also inhibits the COX-2 enzyme. According to authors Thomas M Newmark and Paul Schulick of Beyond Aspirin (HOHM Press, 2000), ‘ginger not only safely modulates COX-2, but it also safely brings balance to COX-1 enzyme activity in a manner that is vastly superior to the synthetic NSAIDS, like aspirin’.
  • ** Green Tea contains the potent COX-2 inhibitors salicylic acid and polyphenols. A 1999 study published in the US Government’s Proceedings of the National Academy of Science refers to the polyphenols in green tea as having a ‘marked reduction’ on COX-2 induced arthritis.5 Several experiments also suggest that they possess potent anti-cancer properties, particularly for cancers of the stomach, small intestine, pancreas, colon, lung and breast.6,7,8
  • ** Rosemary. In 1998, Swedish scientists identified the COX-2 inhibiter ursolic acid in rosemary. It also contains apigenin, which researchers at the National University of Taiwan claim to be a, ‘markedly active inhibitor of COX-2’.
  • ** Hu Zhang (Polygonum cuspidatum). This herb, which is native to Japan, is the richest known source of a polyphenol called resveratrol, which acts as a powerful antioxidant and inhibitor of COX-2.9
  • ** Chinese Goldthread and Barberry both contain a compound called berberine that prevents excess amounts of COX-2. Besides its anti-inflammatory and anti-microbial properties, berberine has also been shown to exert an anti-cancer action in a number of studies. 10
  • ** Oregano contains four compounds – apigenin, kaempherol, ursolic acid and oleanolic acid – that have displayed COX-2 inhibiting effects.
  • ** Scutellaria contains the flavonoid baicalein which suppresses COX-2. Korean scientists have found that scutellaria stimulates an important cancer detoxification enzyme called quinone reductase.11

In addition, researchers in Japan have demonstrated that scutellaria is able to inhibit the spread of colon cancer.12

Laboratory tests conducted at the Department of Urology, Columbia University in New York, and led by scientists Debra Bemis, PhD and Aaron Katz, MD, found that the combined herbs in Zyflamend were able to slow the growth of prostate cancer cells.13

In addition, Zyflamend also doubled the rate at which the cancerous cells self-destructed, a natural anti-cancer activity known as apoptosis or programmed cell death.

What to take for best results

The recommended dosage is one Zyflamend capsule taken twice a day with your main meal and with a glass of water.

WARNING: Women who are pregnant or trying for a baby should consult their GP before taking Zyflamend.

Arthritis Related Reading:

Revisiting The Benefits Of Turmeric

Prostate cancer: The low down on flaxseed and prostate cancer

Protect Prostate Health With Zyflamend


Lower Your Cholesterol And Protect Your Heart Without Statin Drugs

Echinacea And Astragalus : Powerful Immune Boosters

Food and Prescription Medicine: A Potentially Dangerous Cocktail


Bear in mind all the material in this email alert is provided for information purposes only. We are not addressing anyone’s personal situation. Please consult with your own physician before acting on any recommendations contained herein.


1. Natural cyclooxygenase inhibitors and their potential activities against prostate cancer, Columbia-Presbyterian Medical Center, Summer 2002.
2. Dr James Duke, The most important medicine you’ll ever grow: COX-2 inhibitors can ease pain and fight cancer – naturally. Special report Natural Health, part two.
3. Honda, SN et al. Novel triterpenoids suppress inducible nitric oxide synthase and inducible cyclooxygenase in mouse macrophages. Cancer Res 1998;58(4):717-23.
4. Deodhar SD, Sethi R, Srimal RC. Preliminary studies on antirheumatic activity of curcumin (diferuloyl methane). Ind J Med Res 1980;71:632-4.
5. Haqqi TM, et al. prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA 1999;96(8):4524-9.
6. Mukhtar H, Ahmad N. Green tea in chemoprevention of cancer. Toxicol Sci 1999;52(2 Suppl):111-7.
7. Katiyar SK, Mukhtar H. Tea consumption and cancer. World Rev Nutr Diet 1996;79:154-84 [review].
8. Kohlmeier L, Weterings KG, Steck S, Kok FJ. Tea and cancer prevention: an evaluation of the epidemiologic literature. Nutr Cancer 1997;27:1-13 [review].
9. Thomas M Newmark and Paul Schulick, Beyond Aspirin, HOHM Press 2000.
10. Fukuda K, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66(2):227-33.
11. Park HJ, et al. induction of quinone reductase by a methanol extract of scutellaria baicalensis and its flavonoids in murine hepa 1c1c7 cells. Eur J Cancer Prev 1998;7(6):465-71.
12. Fukutake M, et al. Inhibitory effect of coptidis rhizoma and scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Boil Pharm Bull 1998;21(8):814-7.
13. Bemis DL, Katz AE et al. Zyflamend, An herbal COX-2 inhibitor with in vitro anti-prostate-cancer activity. Center for Holistic Urology, Department of Urology, Columbia University, New York.

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  • I was told I had RA 2 weeks ago. But 3 months ago I was told I had Epstein-Barr and another doctor advised that my blood test results showed “exposure” to Lyme Disease”. I told them I am allergic to SLS (Sodiim Laurel Sulfate), but they don’t want to listen (cause there are no tests in USA for SLS). What I’ve read so far about RA, is that it’s the most mis-diagnosed disease on the market these days, because the symtoms mimick so many other diseases. So I decided to “Fight Back” and start taking Zylamend! I’ve only been on it for 3 days, but find my horrible aches are not as horrible when I first wake up. I won’t take steroids unless it’s a “life or death” situation. I’ve had great health until Oct 2008, when I was exposed to an overdoes of SLS in improperly used rug shampoo (don’t ask). I had a bout with Epstein-Barr in the mid 1990’s and cured myself with herbs and supplements. From time to time, a dr would check my RA numbers and I was fine. So they expect me to believe that one day I am fine, and the next after being overdosed with SLS (in the rug shampoo), and covered with hives, rashes and going into anaphalectic shock, I now have RA and have to take steroids. Something is wrong with this picture.

    So, for a little while, I’m sticking with Zyflamend. I’ll report in, in a few weeks, to tell you all how I am doing.

    Take care all!

  • I have been taking Zyflmend for about 8 weeks for prosate my psa went down by half, since I have been taking the pills twice daily. I have had some gas and loose bowels but if this trend continues I will deal with the side effects.

  • I’d like to hear from Sue, Jamie & Lori regarding the increase in pain with Zyflmend. My husband and I also experienced this and we contacted New Chapter and were told “Generally, Zyflamend does not lead to an exacerbation of symptoms; however, it usually takes the formula 4-6 weeks before reaching full efficacy.” My husband is still taking Zyflamend at a reduced dosage and I have stopped taking it, but am planning on starting it on a reduced dosage. I am curious if your pain has decreased after a certain time.

  • I have been taking 2 caps twice a day while dieting so not with a big meal. Is this bad? I have been on it for about 2 weeks and don’t feel any different. I have pain and stiffness in my ankles everyday. It has not gone away. Or any other aches. I don’t get it, everyone else seem to get relief. How much can you actually take? Is more better?

  • I am so grateful to see Jamie’s and Sue’s posts about the increased pain when starting Zyflamend! I started it 2 days ago for severe knee arthritis and had a good day yesterday until last night when the pain in my knee returned and I couldn’t walk or sleep. I thought I was having an adverse reaction but after reading these posts I will stick with it and expect to improve. Thank you, Jamie and Sue for posting – I searched all over for this info because I suspected it might be a normal response. This is not mentioned in any of the side effects that are listed.

  • I have had condromalasia patella in both my knees for many, many years and suffered constant knee pain due to inflammation caused by the disease. I am a cyclist and was experiencing a high degree of inflammation due to the stress on the knees. Whereas cycling is often considered a good exercise for the knees, it was causing some problems in my case. I started taking the zyflamend at the recommended dosage but have increase it now and am taking 2 softgels twice daily and have had great results. I can ride more and have much less pain the following day. Does anyone know if there’s any harm in taking 4 softgels/day?

  • I am 24 years old with arthritis in my ankle. Every doctor that I went to tried to put me on all sorts of medicine like predisone, methotrexate, sulfasalazine and they all gave me horrible side effects. Too young to deal with that crap and so I decided to be my own doctor. Thank you ZYFLAMEND cause now I can walk without feeling horrible about taking a pill every day. I do get some gas as a side effect but I rather have that over anything else!

  • On my third day I experienced an anxiety attack, I took Zoloft for this. Has anyone experienced increased anxiety form zyflamend or know why this would increase anxiety?

  • Just want to let Jody and others know that I had chronic knee swelling and terrible knee pain for 9 months. Nothing seemed to help. I was told by my doctor that I had arthritis which was more advanced for my age than it should have been – and that he couldn’t do anything for me. I did go for physical therapy which strengthened my quadriceps, which support the knee, but I still had swelling and some discomfort. I decided to look into zyflamend, which I have been taking on and off, as needed, for about 2-3 years with exceptional results. I now teach dance and fitness! I also take MSM for arthritis and fish oil supplements, but I believe the zyflamend has been curative. If I feel that my knees are starting to ache again, I simply take zyflamend that day feel better the next.

  • I was diagnosed with Fibromyalgia a little over 2 wks ago. My GP sent me home with a trial sample of Savella, which is in the anti depressant drug. I noticed a bit of improvement with the pain in my legs after about 6 or 7 days, however, I am into my 3rd week and today had a really bad day, just hurting everywhere. I didn’t want to get out of bed but finally forced myself to take a hot shower. I am also feeling the some of the side effects from Savella (nausea, shortness of breath, headaches, red flushing of my face, confusion). I would like to know if anyone taking Zyflamend has used it for chronic pain from Fibromyalgia?

  • My question is about dosage. I was told in a health food store that I should take 2 gelcaps 3 times a day. Can that hurt me since the recommended dosage is 2 gelcaps a day? I haven’t started yet but am anxious to start for arthritis in my hand.

  • I got almost immediate relief from Zyflamend for my back – I have 3 herniated discs, stenosis, arthritis, and spondylolethesis – after the first week…..to start, you take 1 per day…..I can’t imagine what taking 2 per day will do!! I no longer have to take the stuff that makes me sick to my stomach and that gives me rebound headaches. Is it possible to become immune to it? Should I take a break from it so I don’t become immune to it?

  • Has anyone with constant knee pain tried taking Zyflamend?

    What about anyone with MS?

  • I would like to try zyflamend. I have hepatitis c. Are there any ingredients in zyflamend that are bad for the liver. I’m thinking of taking it for inflamation in my ankel, but with my liver disease I have to make sure that it is liver friendly before taking it.

  • Sue, I found this as a search for adverse reactions because since taking this ny husband & I have joint pain EVERYWHERE. You have a positive outlook in reference to this, can you email me to discuss in detail before I stop taking it. Thank you.

  • Sue! Yes, I actually came across this post because I am doing a search about adverse reactions. My husband & I are getting joint pain everywhere! You have a more positive outlook about it, we were thinking about whether we should stop taking it?

  • On the advice of our holistic health care provider, my husband and I have been taking Zyflamend (2/day) for the past month to reduce elevated CRP levels (C-Reactive Protein). The results to-date have been pretty bizarre. We are convinced that it is targetting areas of our bodies where we have had past injuries (sprains, strains, ear infections, etc) in an attempt to heal unresolved inflammation. Out of the blue, these long dormant injured areas on both our bodies are gradually flaring up (even to the point of bruising, swelling, and tenderness) and depending on the extent of the past injuries will stay inflamed for a few days then gradually clear up. Our hypothesis is that it is attacking dormant areas of inflammation that never quite healed effectively. Is anyone else out there experiencing this bizarre reaction? We hope and want to believe this is a good thing that is happening … but sometimes reliving the aches and pains of our past isn’t the most pleasant experience. We will continue on Zyflamend for several months then have our CRP levels rechecked. Hopefully Zyflamend is doing it’s ‘thing’!

  • Are there any drug-interaction problems with Zyflamend? I take Avapro and Lovastatin.

  • I wonder if there are any negative drug-interactions when one takes Avapro; and also Zyflamend? My doctor has no idea. I also take Lovastatin. Is it okay for me to take Zyflamend? I am 72. Male. Thanks for your advise.

  • My dog has been diagnosed with aggresive lymphoma cancer, which has spread to the bone marrow, do you think this product will help?

  • I suffer from Ulcerative Collitis, which is a horrible chronic inflammation of the lower intestine. About three yrs ago I came upon Zyflamend LIQUID and this product is AMAZING! The Liquid is quicker thus take it under the tongue, tolerate it as long as you can, as it taste pretty bad, then drink it down. Also give it to my older arthritic dogs in the pill form though.

  • Zyflamend supports Normal cell growth function is an excellent product and I do believe in it. There are a few products that I feel. Zyflamend excellent for waking up the cell growth and Zyflamend is one of them.

  • I am a man that likes to play the guitar
    But do to arthritis in my finger it inflames to the point where I can not play.
    Also being a survivor on kidney dialysis for 32 years I am now 52.
    Can I takeZyflamend being a dialysis patient?

  • I have an ongoing back problem but cannot take anti inflammatories as they make me very sick and give me headaches. I am a big fan of natural alternatives to traditional medicines and eagerly bought Zyflamend following a personal recommendation and information on web pages like this.
    I have quite a low resistance to any drugs so only took one capsule the first day. Unfortunately, I found that it affected my balance, eye sight and hearing quite dramatically. I kept stumbling when I got up or moved around. I developed a buzzing in my ear and the room spun from time to time. The symptoms were rather like a short bout of labyrinthitis I had many, many years ago. Needless to say, I won’t be taking this herbal remedy any more.

  • I just purchased Zyflamend, and the PM as well. I have RA, and hope to get some positive results!

  • As a rule I never comment on anything, but after attending a seminar on “Easing the pain of inflammation, where Zyflamend was recommended, I am absolutely amazed at the difference the first 2 pills have made. I had extreme pain in my hands and the Vioxx and Celebrex made me so sick I quite taking it and OTC pain medicine took the edge off, but never completely relieved the pain. I actually had several hours today where I didn’t even think about the pain in my hands. I can only hope it gets better and better as the days go by.

  • I have been diagnosed with cervical stenosis and partial paralysis of the vocal chords and neck muscles (due to complications during surgery). Pain has been there every minute, every day – the only variant is the degree of pain. At least once a week, the pain is so severe that I am confined to the bed and hot showers in an effort to find any amount of comfort. Narcotic pain killers make me sick to my stomach, muscle relaxants leave me too drowsy to function, and nerve pain medication have other adverse effects for me.

    I have been taking Zyflamend for about two weeks now. The first week, I honestly did not feel any different. However, for the past 7 days, I have been off all prescription medication. (I still need to take OTC medication some times.) I can honestly say that I do not feel the intensity of pain that I lived with before. I’m not 100% – there is some amount of “discomfort”, or dull pain sensation; however, nothing compared to the debilitating level of pain prior to Zyflamend.

    I still can’t believe the results, and hope that I don’t develop a resistance to Zyflamend. If you suffer from any kind of pain, I highly recommend that you try a bottle. Keep in mind, that it took 2 weeks before I felt any difference at all – so don’t stop taking it, if you don’t notice something right away.

  • I am taking the zyflamend for nighttime back pain and it is truly a breath of fresh air. I am sleeping great with very minimal pain. Also recommending in the clinic where I work.

  • I too, am a musician, a violin, violist and count on playing to make a living. As I grow older, I notice I hurt sooner and sooner and don’t bounce back after a few days of not playing like when I was younger.

    I’m trying zyfamend and it’s helping slightly. I also pinch the problem areas (a physical therapist I went to see in L.A. does this method, which helps), which does hurt, but breaks up the inflammation. I’m going to double the dose soon (Zyflamend) and see if it works any better. Will keep you posted..

  • I suffer from HLA-B27 and inflammation pain. As a music teacher, I play the piano and work with children, young people and adults. It is important to keep fit and happy. Work hard is my ambition , makes me feel free and sometimes the pain does not allow me to, in my homework. My physician does not help me in the right way because he does not believe I should work any more.

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