How Vitamin D Can Help To Maintain Prostate Health

0 Comments

The benefits of vitamin D for prostate health may be due to the action of the vitamin on a specific gene, suggests new research that deepens our understanding of how nutrients and genes interact.

US researchers from the University of Rochester Medical Center report that the active form of vitamin D in the body, 1,25-hydroxylvitamin D3 (1,25(OH)2D), may link with a gene known as G6PD, which releases an antioxidant enzyme and protects DNA from damage.

According to lead researcher Yi-Fen Lee: “Many epidemiological studies have suggested the beneficial properties of vitamin D. Our findings reflect what we see in those studies and demonstrate that vitamin D not only can be used as a therapy for prostate cancer it can prevent prostate cancer from happening.”

Prostate Health: Two sides of the vitamin

Vitamin D refers to two biologically inactive precursors – D3, also known as cholecalciferol, and D2, also known as ergocalciferol. Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25- hydroxyvitamin D (25(OH)D), the non-active ‘storage’ form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

There is growing evidence that 1,25(OH)2D has anticancer effects, but the discovery that non-kidney cells can also hydroxylate 25(OH)D had profound implications, implying that higher 25(OH)D levels could protect against cancer in the local sites.

Prostate Health: Assessing the results

The new study, supported by a grant from the US Department of Defense, appears to provide further compelling evidence of the potent anti-cancer benefits of 1,25(OH)2D.

Normal healthy prostate cells (BPH-1 and RWPE-1) and prostate cancer cells (CWR22R and DU 145) were subjected to oxidative stress. The researchers found that 1,25(OH)2D induced G6PD (glucose-6-phosphate dehydrogenase), a key antioxidant enzyme, in the healthy but not cancer cells. G6PD scavenges reactive oxygen species (ROS) associated with DNA damage.

Commenting on the findings Lee said: “If you reduce DNA damage, you reduce the risk of cancer or ageing. Our study adds one more beneficial effect of taking a vitamin D supplement. Taking a supplement is especially important for senior citizens and others who might have less circulation of vitamin D, and for people who live and work areas where there is less sunshine.”

??In this study, we have demonstrated that 1,25-(OH)2D can protect non-malignant human prostate epithelial cells against H2O2-induced cell death through modulating the ROS defence systems, suggesting a possible role of 1,25-(OH)2D in prostate cancer prevention”.

Prostate Health: Vitamin D – bad for cancers, good for you

Lee and his fellow researchers noted that 1,25(OH)2D may act both as an antioxidant and a pro-oxidant, depending on the cellular environment, with a subtle pro-oxidant activity found in cancer cells, while it appears to behave as an antioxidant in normal healthy cells.

“[Our] data suggest that vitamin D might exert a subtle oxidative stress, which could stimulate the detoxification mechanisms to protect cells from the subsequent stress challenges; yet cancer cells lose the 1,25-(OH)2D-induced detoxification responses, therefore, 1,25-(OH)2D acts as a pro-oxidant in cancer cells,” they said.

“Our results provide one mechanism to explain how 1,25-(OH)2D protects non-malignant human prostate epithelial cells from oxidative stress to attenuate the accumulation of oxidative damages during the life.

“Therefore, vitamin D might be beneficial for preventing the development of age-dependent diseases,” they concluded.


Disclaimer: This article is part of the Daily Health's extensive research archive. The research and information contained in this article was accurate at the the time of publication but may have been updated since the date of publication. Consult our most recent articles for the latest research on alternative health and natural breakthroughs.

Bear in mind the material provided in this content is for information purposes only. We are not addressing anyone’s personal situation. Please consult with your own physician before acting on any recommendations contained herein.

Print Friendly

Don't Forget Your Free Report



Just RSVP below for immediate access to this valuable report, with our sincere compliments.

As you'll discover in your FREE report, there are safe, natural ways to protect your heart without the use of risky, side-effect-ridden drugs.

And that's not all. When you enter your email address, you'll also receive the Daily Health e-letter. Each day in the Daily Health, you'll get:

• News on the latest cutting-edge natural health breakthroughs.
• The truth behind mainstream health headlines
• First access to new product releases
• And much, much more!

Enter your email address below to receive your FREE report, 10 Steps To Healthy Cholesterol Levels. We'll deliver it straight to your inbox in a matter of minutes.

10 Steps To Healthy Cholesterol Levels



Just RSVP below for immediate access to this valuable report, with our sincere compliments.

As you'll discover in your FREE report, there are safe, natural ways to protect your heart without the use of risky, side-effect-ridden drugs.

And that's not all. When you enter your email address, you'll also receive the Daily Health e-letter. Each day in the Daily Health, you'll get:

• News on the latest cutting-edge natural health breakthroughs.
• The truth behind mainstream health headlines
• First access to new product releases
• And much, much more!

Enter your email address below to receive your FREE report, 10 Steps To Healthy Cholesterol Levels. We'll deliver it straight to your inbox in a matter of minutes.